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A case of hemophagocytic syndrome progressing into large granular lymphoma in a dog.
- Source :
-
Veterinary clinical pathology [Vet Clin Pathol] 2019 Mar; Vol. 48 (1), pp. 71-77. Date of Electronic Publication: 2019 Feb 27. - Publication Year :
- 2019
-
Abstract
- A 12-year-old castrated male mixed breed dog was presented with anorexia, lethargy, intermittent vomiting, diarrhea, and weight loss. Clinicopathologic and imaging abnormalities included pancytopenia, icterus, and splenomegaly with multiple minute hypoechogenic nodules. Bone marrow (BM) smears revealed 2.5% hemophagocytic macrophages. In addition, an increased number of small to intermediate lymphocytes (16.3%) and plasma cells (3.2%) were recognized in the BM smears. More than 80% of the lymphocytes contained multiple small intracytoplasmic magenta granules. Histopathologic findings of the spleen revealed hemophagocytosis. Large granular lymphocytes (LGLs) were not found on the liver cytology or splenic histopathology at this time. PCR for antigen receptor rearrangement (PARR) analysis showed a clonal reaction in the T-cell receptor ɤ (TCRɤ) gene in the BM sample. The dog was diagnosed with hemophagocytic syndrome (HPS). The dog was maintained in good condition with immunosuppressive therapy. However, the dog developed hepatic LGL lymphoma 7 months later. At this time, PARR analysis showed a clonal TCRɤ gene rearrangement in the hepatic LGL lymphoma samples. The BM and liver sample clonal rearrangements showed 100% homology, indicating that the small to intermediate granular lymphocytes in the BM at the HPS stage had progressed to hepatic LGL lymphoma. To our knowledge, this is the first report of canine secondary HPS caused by the occurrence of a BM LGL lymphoma clone that progressed to hepatic LGL lymphoma.<br /> (© 2019 American Society for Veterinary Clinical Pathology.)
- Subjects :
- Animals
Bone Marrow pathology
Disease Progression
Dog Diseases diagnosis
Dogs
Liver pathology
Lymphohistiocytosis, Hemophagocytic diagnosis
Lymphohistiocytosis, Hemophagocytic pathology
Lymphoma diagnosis
Lymphoma pathology
Male
Dog Diseases pathology
Lymphohistiocytosis, Hemophagocytic veterinary
Lymphoma veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1939-165X
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Veterinary clinical pathology
- Publication Type :
- Report
- Accession number :
- 30811622
- Full Text :
- https://doi.org/10.1111/vcp.12704