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A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2019 Jun 01; Vol. 130, pp. 508-514. Date of Electronic Publication: 2019 Feb 28. - Publication Year :
- 2019
-
Abstract
- Neutral polysaccharides from Ningxia L. barbarum fruit have been reported with immunomodulatory and antioxidative biological activities. Few studies on pectic polysaccharides have been reported, especially not from the Xinjiang L. barbarum. In the present study, a pectic polysaccharide, XLBP-I-I, was obtained from water decoction of Xinjiang L. barbarum using anion exchange chromatography and gel filtration. The results from methanolysis, methylation, FT-IR and NMR experiments indicated that XLBP-I-I was a typical pectic polysaccharide. In vitro assay showed that XLBP-I-I could reduce the ER stress and UPR in tunicamycin insult IPEC-J2 cells, and further protect IPEC-J2 cells against apoptosis induced by ER stress. These results reveal a new perspective for pectic L. barbarum polysaccharides on intestine ER stress, and this elicited interests for its further applications.<br /> (Copyright © 2019. Published by Elsevier B.V.)
- Subjects :
- Cell Line
Cell Survival drug effects
Intestinal Mucosa drug effects
Intestinal Mucosa metabolism
Molecular Weight
Phytochemicals chemistry
Phytochemicals pharmacology
Polysaccharides chemistry
Protective Agents chemistry
Protective Agents pharmacology
Endoplasmic Reticulum Stress drug effects
Fruit chemistry
Lycium chemistry
Plant Extracts chemistry
Plant Extracts pharmacology
Polysaccharides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 130
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 30826406
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2019.02.157