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Childhood methylphenidate adherence as a predictor of antidepressants use during adolescence.
- Source :
-
European child & adolescent psychiatry [Eur Child Adolesc Psychiatry] 2019 Oct; Vol. 28 (10), pp. 1365-1373. Date of Electronic Publication: 2019 Mar 04. - Publication Year :
- 2019
-
Abstract
- Methylphenidate (MPH) is a common and effective treatment for attention deficit hyperactivity disorder (ADHD), but little is known about the relationship between early childhood intake of MPH and onset of antidepressant treatment during adolescence. The study aimed to examine whether adherence to MPH during early childhood predicts the initiation of antidepressants during adolescence. This is a 12-year historical prospective nationwide cohort study of children enrolled in an integrated care system who were first prescribed MPH between the ages of 6 and 8 years (Nā=ā6830). We tested for an association between their adherence to MPH during early childhood (as indicated by medication possession ratio from MPH onset through the age of twelve) and the likelihood of being prescribed any antidepressant during adolescence (age 13-18). As all country citizens are covered by mandatory health insurance, and full services are provided by one of the four integrated care systems, data regarding patients' diagnoses, prescriptions, and medical purchases are well documented. Logistic regression analysis indicated that those with higher adherence to MPH had a 50% higher risk (95% CI 1.16-1.93) of receiving antidepressants during adolescence when controlling for other comorbid psychiatric conditions and parental use of antidepressants. In this large-scale longitudinal study, MPH adherence during early childhood emerged as a predictor for antidepressant treatment during adolescence, which may reflect increased emotional and behavioral dysregulation in this group. The highly adherent patients are at higher risk and should be clinically monitored more closely, particularly into adolescence.
- Subjects :
- Antidepressive Agents pharmacology
Central Nervous System Stimulants pharmacology
Child
Cohort Studies
Female
Humans
Longitudinal Studies
Male
Methylphenidate pharmacology
Prospective Studies
Treatment Outcome
Antidepressive Agents therapeutic use
Central Nervous System Stimulants therapeutic use
Depression drug therapy
Methylphenidate therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1435-165X
- Volume :
- 28
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- European child & adolescent psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 30828744
- Full Text :
- https://doi.org/10.1007/s00787-019-01301-z