Back to Search
Start Over
Ni(NIXANTPHOS)-Catalyzed Mono-Arylation of Toluenes with Aryl Chlorides and Bromides.
- Source :
-
Organic letters [Org Lett] 2019 Mar 15; Vol. 21 (6), pp. 1735-1739. Date of Electronic Publication: 2019 Mar 06. - Publication Year :
- 2019
-
Abstract
- A nickel-catalyzed cross-coupling of toluene derivatives with both aryl bromides and chlorides using a NIXANTPHOS-ligated nickel(II) complex has been developed. The key factor to success is proposed to be the catalyst activation of toluene by a cation-π complex, enabling methyl arenes (p K <subscript>a</subscript> ≈ 43) to be deprotonated with the relatively mild base NaN(SiMe <subscript>3</subscript> ) <subscript>2</subscript> . This method facilitates access to a variety of sterically and electronically diverse hetero- and nonheteroaryl-containing diarylmethanes.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 30838860
- Full Text :
- https://doi.org/10.1021/acs.orglett.9b00294