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Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Biomarkers of Oxidative Stress and Inflammation in Healthy Adults: A Randomized Double-Blind Controlled Trial.
- Source :
-
Nutrients [Nutrients] 2019 Mar 06; Vol. 11 (3). Date of Electronic Publication: 2019 Mar 06. - Publication Year :
- 2019
-
Abstract
- A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of triterpenes), and a functional olive oil (FOO, 487 ppm of phenolic compounds and enriched with 389 ppm of triterpenes) supplementation (30 mL per day) during three weeks would provide additional health benefits to those produced by a standard VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes) on oxidative and inflammatory biomarkers. Fifty-one healthy adults participated in a randomized, crossover, and controlled study. Urinary 8-hidroxy-2'-deoxyguanosine, plasma interleukin-8 (IL-8), and tumor necrosis factor α (TNF- α) concentrations were lower after the intervention with the FOO than after the OVOO ( p = 0.033, p = 0.011 and p = 0.020, respectively). In addition, IL-8 was lower after the intervention with FOO than after VOO intervention ( p = 0.002). This study provides a first level of evidence on the in vivo health benefits of olive oil triterpenes (oleanolic and maslinic acids) in healthy humans, decreasing DNA oxidation and plasma inflammatory biomarkers. The trial was registered in ClinicalTrials.gov ID: NCT02520739.
- Subjects :
- Adult
Biomarkers blood
Cross-Over Studies
Double-Blind Method
Female
Healthy Volunteers
Humans
Inflammation
Intention to Treat Analysis
Male
Middle Aged
Olive Oil administration & dosage
Young Adult
Inflammation Mediators blood
Olive Oil chemistry
Oxidative Stress drug effects
Phenols pharmacology
Triterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 30845690
- Full Text :
- https://doi.org/10.3390/nu11030561