Back to Search
Start Over
Serum antibody profiles in individuals with latent Mycobacterium tuberculosis infection.
- Source :
-
Microbiology and immunology [Microbiol Immunol] 2019 Mar; Vol. 63 (3-4), pp. 130-138. Date of Electronic Publication: 2019 Apr 09. - Publication Year :
- 2019
-
Abstract
- One-third of the world's humans has latent tuberculosis infection (LTBI), representing a large pool of potentially active TB. Recent LTBI carries a higher risk of disease progression than remote LTBI. Recent studies suggest important roles of antibodies in TB pathology, prompting us to investigate serum antibody profiles in a cohort with LTBI. In this single-center prospective observational study, we analyzed IgG-antibody concentrations against five major Mycobacterium tuberculosis (Mtb) antigens (including 6 kDa early secretory antigenic target (ESAT6), CFP10, and antigen 85A, which are expressed mainly in the growth phase; and mycobacterial DNA-binding protein 1 (MDP1) and alpha-crystallin like protein (Acr), which are expressed in the dormant phases) in individuals with recent (n=13) or remote (n=12) LTBI, no Mtb infection (n=19), or active TB (n=15). Antibody titers against ESAT6 and MDP1 were significantly higher in individuals with recent LTBI than in those with no Mtb infection or remote LTBI. All pairwise antibody titers against these five major antigens were significantly correlated throughout the stages of Mtb infection. Five individuals with recent LTBI had significantly higher antibody titers against ESAT6 (P = 0.03), Ag85A (P = 0.048), Acr (P = 0.057), and MDP1 (P = 0.0001) than in individuals with remote LTBI; they were also outside the normal range (+2 SDs). One of these individuals was diagnosed with active pulmonary TB at 18-month follow-up examination. These findings indicated that concentrations of antibodies against both multiplying and dormant Mtb are higher in recent LTBI and that individuals with markedly higher antibody titers may be appropriate candidates for prophylactic therapy.<br /> (© 2019 The Societies and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Acyltransferases immunology
Adult
Antibodies, Bacterial immunology
Bacterial Proteins immunology
DNA-Binding Proteins immunology
Female
Humans
Immunoglobulin G blood
Immunoglobulin G immunology
Latent Tuberculosis microbiology
Male
Middle Aged
Prospective Studies
Tuberculosis, Pulmonary microbiology
alpha-Crystallins immunology
Antibodies, Bacterial blood
Antigens, Bacterial immunology
Latent Tuberculosis immunology
Mycobacterium tuberculosis immunology
Tuberculosis, Pulmonary diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1348-0421
- Volume :
- 63
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Microbiology and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30851131
- Full Text :
- https://doi.org/10.1111/1348-0421.12674