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Plugged into the Ku-DNA hub: The NHEJ network.

Plugged into the Ku-DNA hub: The NHEJ network.

Authors :
Frit P
Ropars V
Modesti M
Charbonnier JB
Calsou P
Source :
Progress in biophysics and molecular biology [Prog Biophys Mol Biol] 2019 Oct; Vol. 147, pp. 62-76. Date of Electronic Publication: 2019 Mar 06.
Publication Year :
2019

Abstract

In vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken DNA ends forming a recruiting hub. Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized proteins with scaffolding and/or enzymatic properties. To shed light on these dynamic interplays, we review here current knowledge on proteins directly interacting with Ku and on the contact points involved, with a particular accent on the different classes of Ku-binding motifs identified in several Ku partners. An integrated structural model of the core NHEJ network at the synapsis step is proposed.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1873-1732
Volume :
147
Database :
MEDLINE
Journal :
Progress in biophysics and molecular biology
Publication Type :
Academic Journal
Accession number :
30851288
Full Text :
https://doi.org/10.1016/j.pbiomolbio.2019.03.001