Back to Search
Start Over
Choice of surgical procedure - lobectomy, segmentectomy, or wedge resection - for patients with stage T1-2N0M0 small cell lung cancer: A population-based study.
- Source :
-
Thoracic cancer [Thorac Cancer] 2019 Apr; Vol. 10 (4), pp. 593-600. Date of Electronic Publication: 2019 Mar 10. - Publication Year :
- 2019
-
Abstract
- Background: To date, few studies have evaluated the impact of lobectomy versus sublobar resection for early small cell lung cancer (SCLC). We investigated the survival rates of patients with pathological stage T1-2N0M0 SCLC who underwent lobectomy or sublobar resection.<br />Methods: We identified 548 SCLC patients in the Surveillance, Epidemiology, and End Results database who underwent lobectomy or sublobar resection. Propensity score matching (PSM) and Cox regression analysis were used to adjust for baseline characteristics.<br />Results: The three-year overall survival (OS) of patients treated with lobectomy (n = 376, 60%) was significantly higher than those treated with sublobar resection (n = 172, 38%). PSM and Cox multivariable analysis further confirmed this result (hazard ratio [HR] 0.543, 95% confidence interval [CI] 0.421-0.680; P < 0.001). The three-year OS of patients treated with segmentectomy (n = 24, 54%) and wedge resection (n = 148, 36%) was not significantly different (HR 0.639, 95% CI 0.393-1.039; P = 0.071). Based on PSM analysis, segmentectomy conferred a superior survival advantage to patients relative to wedge resection (HR 0.466, 95% CI 0.221-0.979; P = 0.040).<br />Conclusion: Lobectomy correlated with superior survival. For patients in which lobectomy is unsuitable, prognosis following segmentectomy appears to be better than after wedge resection.<br /> (© 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Lung Neoplasms mortality
Lung Neoplasms pathology
Male
Middle Aged
Neoplasm Staging
Patient Preference
Pneumonectomy mortality
Prognosis
Propensity Score
Regression Analysis
Retrospective Studies
SEER Program
Small Cell Lung Carcinoma mortality
Small Cell Lung Carcinoma pathology
Survival Analysis
Treatment Outcome
Lung Neoplasms surgery
Pneumonectomy methods
Small Cell Lung Carcinoma surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1759-7714
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Thoracic cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30854808
- Full Text :
- https://doi.org/10.1111/1759-7714.12943