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Weekly cisplatin chemotherapy dosing versus triweekly chemotherapy with concurrent radiation for head and neck squamous cell carcinoma.
- Source :
-
Head & neck [Head Neck] 2019 Aug; Vol. 41 (8), pp. 2492-2499. Date of Electronic Publication: 2019 Mar 11. - Publication Year :
- 2019
-
Abstract
- Background: Triweekly high-dose cisplatin (100 mg/m <superscript>2</superscript> ) with concurrent radiation therapy is the current standard of care in the definitive or appropriate postoperative setting in head and neck squamous cell carcinoma (HNSCC). We compared triweekly 100 mg/m <superscript>2</superscript> with alternative weekly 40 mg/m <superscript>2</superscript> and weekly <40 mg/m <superscript>2</superscript> cisplatin regimens.<br />Methods: From 2011 to 2016, 163 patients received concurrent cisplatin and intensity-modulated radiotherapy for locally advanced HNSCC. Primary endpoints were overall survival (OS) and progression-free survival.<br />Results: Cisplatin weekly <40 mg/m <superscript>2</superscript> showed inferior OS outcomes when compared to weekly 40 mg/m <superscript>2</superscript> (P = 0.084) and triweekly 100 mg/m <superscript>2</superscript> (P = 0.04) regimens.<br />Conclusion: Our study displayed inferior outcomes with weekly cisplatin doses under 40 mg/m <superscript>2</superscript> , suggesting the inferiority of low-dose weekly chemotherapy and the need for ongoing randomized trials to further explore 40 vs 100 mg/m <superscript>2</superscript> chemotherapy regimens.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Aged
Antineoplastic Agents administration & dosage
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Progression-Free Survival
Radiotherapy, Intensity-Modulated
Retrospective Studies
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell therapy
Chemoradiotherapy
Cisplatin administration & dosage
Head and Neck Neoplasms mortality
Head and Neck Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 41
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 30856297
- Full Text :
- https://doi.org/10.1002/hed.25717