A clinical study assessing the short-term efficacy of combined in-office/at-home whitening treatment.

Objective: The purpose of this randomized clinical trial was to assess the efficacy of color change in combined in-office/at-home whitening.
Materials and Methods: Thirty participants were randomly divided into two groups: 15 received combined treatment in-office whitening (6% hydrogen peroxide + 2 weeks at-home whitening with 16% carbamide peroxide [CP]); 15 were assigned to control group. Instrumental color measurements were obtained before whitening (t ₀ ), immediately after in-office whitening (t _in-office ), after 1 week of active treatments (t ₁ ), and at the completion of the whitening treatment (t ₂ ). CIE L*a*b* values were recorded and CIE L*a*b* and CIEDE2000 color differences were calculated.
Results: The color change at t _in-office was ΔE _ab = 4.7 and ΔE ₀₀ = 3.2 and overall color change of combined method at t ₂ was ΔE _ab = 8.2 and ΔE ₀₀ = 5.3 (P < 0.05). A statistically significant effect for the mean CIE L*a*b* and CIEDE2000 values was detected within time with the mean a*, b* and C' values decreasing and mean h' values increasing significantly (P < 0.05).
Conclusions: Combined in-office/at-home whitening was effective. Whitening efficacy increased upon application of 16% CP in combined in-office/at-home treatment (P < 0.05).
Clinical Significance: The statistically significant increase in color change recommends clinical application of combined in-office/at-home whitening treatment.
(© 2019 Wiley Periodicals, Inc.)