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Baseline hemoglobin <11.0 g/dL has stronger prognostic value than anemia status in nasopharynx cancers treated with chemoradiotherapy.
- Source :
-
The International journal of biological markers [Int J Biol Markers] 2019 Jun; Vol. 34 (2), pp. 139-147. Date of Electronic Publication: 2019 Mar 13. - Publication Year :
- 2019
-
Abstract
- Background: To retrospectively investigate the influence of pretreatment anemia and hemoglobin levels on the survival of nasopharyngeal carcinoma patients treated with concurrent chemoradiotherapy (C-CRT).<br />Methods: A total of 149 nasopharyngeal carcinoma patients who received C-CRT were included. All patients had received 70 Gy to the primary tumor plus the involved lymph nodes, and 59.4 Gy and 54 Gy to the intermediate- and low-risk neck regions concurrent with 1-3 cycles of cisplatin. Patients were dichotomized into non-anemic and anemic (hemoglobin <12 g/dL (women) or <13 g/dL (men)) groups according to their pre-treatment hemoglobin measures. Receiver operating characteristic (ROC) curve analysis was utilized for accessibility of a pre-treatment hemoglobin cut-off that impacts outcomes. Potential interactions between baseline anemia status and hemoglobin measures and overall survival, locoregional progression-free survival (LRPFS), and progression-free survival were assessed.<br />Results: Anemia was evident in 36 patients (24.1%), which was related to significantly shorter overall survival ( P =0.007), LRPFS ( P <0.021), and progression-free survival ( P =0.003) times; all three endpoints retained significance in multivariate analyses ( P <0.05, for each). A baseline hemoglobin value of 11.0 g/dL exhibited significant association with outcomes in ROC curve analysis: hemoglobin <11.0 g/dL (N=26) was linked with shorter median overall survival ( P <0.001), LRPFS ( P =0.004), and progression-free survival ( P <0.001) times, which also retained significance for all three endpoints in multivariate analyses and suggested a stronger prognostic worth for the hemoglobin <11.0 g/dL cut-off value than the anemia status.<br />Conclusion: Pre-C-CRT hemoglobin <11.0 g/dL has a stronger prognostic worth than the anemia status with regard to LRPFS, progression-free survival, and overall survival for nasopharyngeal carcinoma patients.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell blood
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell therapy
Chemoradiotherapy adverse effects
Female
Follow-Up Studies
Humans
Male
Middle Aged
Nasopharyngeal Neoplasms blood
Nasopharyngeal Neoplasms pathology
Nasopharyngeal Neoplasms therapy
Retrospective Studies
Survival Rate
Treatment Outcome
Young Adult
Anemia etiology
Carcinoma, Squamous Cell mortality
Chemoradiotherapy mortality
Hemoglobins analysis
Nasopharyngeal Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1724-6008
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The International journal of biological markers
- Publication Type :
- Academic Journal
- Accession number :
- 30864463
- Full Text :
- https://doi.org/10.1177/1724600818821688