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Baseline hemoglobin <11.0 g/dL has stronger prognostic value than anemia status in nasopharynx cancers treated with chemoradiotherapy.

Authors :
Topkan E
Ekici NY
Ozdemir Y
Besen AA
Yildirim BA
Mertsoylu H
Sezen D
Selek U
Source :
The International journal of biological markers [Int J Biol Markers] 2019 Jun; Vol. 34 (2), pp. 139-147. Date of Electronic Publication: 2019 Mar 13.
Publication Year :
2019

Abstract

Background: To retrospectively investigate the influence of pretreatment anemia and hemoglobin levels on the survival of nasopharyngeal carcinoma patients treated with concurrent chemoradiotherapy (C-CRT).&lt;br /&gt;Methods: A total of 149 nasopharyngeal carcinoma patients who received C-CRT were included. All patients had received 70 Gy to the primary tumor plus the involved lymph nodes, and 59.4 Gy and 54 Gy to the intermediate- and low-risk neck regions concurrent with 1-3 cycles of cisplatin. Patients were dichotomized into non-anemic and anemic (hemoglobin &lt;12 g/dL (women) or &lt;13 g/dL (men)) groups according to their pre-treatment hemoglobin measures. Receiver operating characteristic (ROC) curve analysis was utilized for accessibility of a pre-treatment hemoglobin cut-off that impacts outcomes. Potential interactions between baseline anemia status and hemoglobin measures and overall survival, locoregional progression-free survival (LRPFS), and progression-free survival were assessed.&lt;br /&gt;Results: Anemia was evident in 36 patients (24.1%), which was related to significantly shorter overall survival ( P =0.007), LRPFS ( P &lt;0.021), and progression-free survival ( P =0.003) times; all three endpoints retained significance in multivariate analyses ( P &lt;0.05, for each). A baseline hemoglobin value of 11.0 g/dL exhibited significant association with outcomes in ROC curve analysis: hemoglobin &lt;11.0 g/dL (N=26) was linked with shorter median overall survival ( P &lt;0.001), LRPFS ( P =0.004), and progression-free survival ( P &lt;0.001) times, which also retained significance for all three endpoints in multivariate analyses and suggested a stronger prognostic worth for the hemoglobin &lt;11.0 g/dL cut-off value than the anemia status.&lt;br /&gt;Conclusion: Pre-C-CRT hemoglobin &lt;11.0 g/dL has a stronger prognostic worth than the anemia status with regard to LRPFS, progression-free survival, and overall survival for nasopharyngeal carcinoma patients.

Details

Language :
English
ISSN :
1724-6008
Volume :
34
Issue :
2
Database :
MEDLINE
Journal :
The International journal of biological markers
Publication Type :
Academic Journal
Accession number :
30864463
Full Text :
https://doi.org/10.1177/1724600818821688