Iridium oxide (IV) nanoparticle-based lateral flow immunoassay.

Authors :: Quesada-González D
Sena-Torralba A
Wicaksono WP
de la Escosura-Muñiz A
Ivandini TA
Merkoçi A
Source :: Biosensors & bioelectronics [Biosens Bioelectron] 2019 May 01; Vol. 132, pp. 132-135. Date of Electronic Publication: 2019 Feb 28.
Publication Year :: 2019
Abstract: Lateral flow biosensors are paper-based devices that allow the detection of different types of analytes with quickness, robustness and selectivity, without leaving behind paper sensors benefits as low-cost, recyclability and sustainability. Nanomaterials have been widely reported in lateral flow biosensors, offering new sensing strategies based on optical or electrical detection techniques. Looking for other advantageous nanomaterials, we propose for the first time the use of iridium oxide (IV) nanoparticles in lateral flow assays for the detection of human immunoglobulin as a model protein. These nanoparticles can be easily prepared and conjugated with biomarkers. Their dark blue color gives a high contrast against the white background of the strips being in this way excellent labels.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)