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Partner social support during pregnancy and the postpartum period and inflammation in 3-month-old infants.
- Source :
-
Biological psychology [Biol Psychol] 2019 May; Vol. 144, pp. 11-19. Date of Electronic Publication: 2019 Mar 15. - Publication Year :
- 2019
-
Abstract
- Prenatal social stress "programs" offspring immune activity in animal models, but how the prenatal social environment affects human offspring inflammation is not known. Here, we test associations between prenatal partner support quality, i.e. positive/helpful support, negative/upsetting support, and their interaction, and infant inflammatory markers. A sample of 113 women from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort were followed from early pregnancy to 3-months postpartum. Partner support quality was measured during pregnancy and the postpartum period. Three-month-old infant blood samples were assayed for inflammatory markers, i.e., adaptive immune markers IFNγ, IL12p70 and IL10. The prenatal positive-by-negative partner support interaction predicted infant IFNγ, IL12p70, and IL10, p's<.035, independent of covariates and postpartum partner support. When negative partner support was high, high positive support predicted higher infant IFNγ, IL12p70, and IL10. As such, partner support during pregnancy that is both highly negative/upsetting and also highly positive/helpful predicted adaptive immunity markers in infants at 3 months of age.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Alberta
Cohort Studies
Female
Humans
Infant
Inflammation
Male
Postpartum Period psychology
Pregnancy
Pregnancy Outcome
Prenatal Exposure Delayed Effects psychology
Stress, Psychological psychology
Young Adult
Inflammation Mediators blood
Pregnancy Complications psychology
Prenatal Exposure Delayed Effects blood
Sexual Partners psychology
Social Support
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6246
- Volume :
- 144
- Database :
- MEDLINE
- Journal :
- Biological psychology
- Publication Type :
- Academic Journal
- Accession number :
- 30885739
- Full Text :
- https://doi.org/10.1016/j.biopsycho.2019.03.005