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Antibacterial Strategy against H. pylori : Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.
- Source :
-
ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Feb 15; Vol. 10 (3), pp. 363-366. Date of Electronic Publication: 2019 Feb 15 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the identification of previously unreported inhibitors of MqnE using a mechanism-guided approach. The best inhibitor shows efficient inhibitory activity against H. pylori (IC <subscript>50</subscript> = 1.8 ± 0.4 μM) and identifies MqnE as a promising target for antibiotic development.<br />Competing Interests: The authors declare no competing financial interest.
Details
- Language :
- English
- ISSN :
- 1948-5875
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- ACS medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 30891141
- Full Text :
- https://doi.org/10.1021/acsmedchemlett.8b00649