Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca v 3.2 T-type voltage-gated calcium channel.

Objectives: Voltage-gated Ca ²⁺ channels (VGCCs) are of central relevance in regulating Ca ²⁺ influx into living cells. The low-voltage activated (LVA) Ca _v 3 T-type Ca ²⁺ channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood. Within the LVA subgroup, Ca _v 3.2 T-type Ca ²⁺ channels seem to be of special importance as qPCR revealed a steady increase in Ca _v 3.2 transcript levels over age, e.g. in the cochlea and spiral ganglion neurons (SGN). Furthermore, pharmacological studies suggested an association between Ca _v 3.2 expression and both age-related and noise-induced hearing loss. Given the potential functional relevance of Ca _v 3.2 VGGCs in sensorineural hearing loss, we recorded gender specific auditory evoked brainstem responses (ABRs) upon both click and tone burst presentation. Here we present auditory brainstem response (ABR) data from Ca _v 3.2 ^+/+ , Ca _v 3.2 ^+/- and Ca _v 3.2 ^-/- mice from both genders which are of value for researchers who want to evaluate how Ca _v 3.2 loss affects basic auditory parameters, e.g. click and tone burst based hearing thresholds, amplitude growth function and peak latencies.
Data Description: Information presented here includes ABR data from age-matched female and male Ca _v 3.2 ^+/+ , Ca _v 3.2 ^+/- and Ca _v 3.2 ^-/- mice and technical aspects of the auditory recording protocol. Data were recorded using a commercially available ABR setup from Tucker Davis Technologies Inc. (TDT). Raw data files (arf.-file format) were exported as txt.-files with free access for analysis.