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Low doses of Bisphenol A have pro-inflammatory and pro-oxidant effects, stimulate lipid peroxidation and increase the cardiotoxicity of Doxorubicin in cardiomyoblasts.
- Source :
-
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2019 Jul; Vol. 69, pp. 1-8. Date of Electronic Publication: 2019 Mar 07. - Publication Year :
- 2019
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Abstract
- Endocrine disrupters are strictly associated to cancer and several cardiovascular risk factors. Bisphenol A (BPA) is an endocrine disrupter commonly used in the manufacturing of plastics based on polycarbonate, polyvinyl chloride and resins. Our study aims to investigate whether BPA may cause pro-oxidative and pro-inflammatory effects on cardiomyoblasts, thus exacerbating the Doxorubicin (DOXO)-induced cardiotoxicity phenomena. We tested the metabolic effects of BPA at low doses analyzing its affections on the intracellular calcium uptake, oxidative stress, lipid peroxidation and production of nitric oxide and interleukins. Co-incubation of BPA and DOXO significantly reduced the cardiomyoblast viability, compared to only DOXO exposure cells. The mechanisms underlying these effects are based on the stimulation of the intracellular calcium accumulation and lipid peroxidation. Notably, BPA increase the production of pro-inflammatory interleukins involved in cardiovascular diseases as well as in DOXO-Induced cardiotoxicity phenomena. This study provides a rationale for translational studies in the field of cardio-oncology.<br /> (Copyright © 2019. Published by Elsevier B.V.)
- Subjects :
- Animals
Calcium metabolism
Cardiotoxicity metabolism
Cell Line, Tumor
Cytokines metabolism
Drug Synergism
Inflammation chemically induced
Inflammation immunology
Inflammation metabolism
Lipid Peroxidation drug effects
Myoblasts, Cardiac metabolism
Nitric Oxide metabolism
Oxidative Stress drug effects
Rats
Reactive Oxygen Species metabolism
Antibiotics, Antineoplastic toxicity
Benzhydryl Compounds toxicity
Cardiotoxicity etiology
Doxorubicin toxicity
Endocrine Disruptors toxicity
Myoblasts, Cardiac drug effects
Phenols toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7077
- Volume :
- 69
- Database :
- MEDLINE
- Journal :
- Environmental toxicology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 30903913
- Full Text :
- https://doi.org/10.1016/j.etap.2019.03.006