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Metal-Free C-2-H Alkylation of Quinazolin-4-ones with Alkanes via Cross-Dehydrogenative Coupling.
- Source :
-
Organic letters [Org Lett] 2019 Apr 05; Vol. 21 (7), pp. 2365-2368. Date of Electronic Publication: 2019 Mar 25. - Publication Year :
- 2019
-
Abstract
- A practically useful approach for the cross-dehydrogenative coupling of quinazolin-4-one with simple nonactivated alkanes is reported. The products were smoothly formed under mild reaction conditions, within short reaction time at ambient temperature. The formation of new Csp <superscript>3</superscript> -Csp <superscript>2</superscript> bonds occurred at the electron-poor C-2 position of quinazolin-4-one. The approach has the potential to be an important tool for the late-stage functionalization of advanced synthetic intermediates and may find many applications in medicinal chemistry.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 21
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 30907598
- Full Text :
- https://doi.org/10.1021/acs.orglett.9b00638