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Relation of IGF-1 and IGFBP-3 with prevalent and incident atrial fibrillation in a population-based study.
- Source :
-
Heart rhythm [Heart Rhythm] 2019 Sep; Vol. 16 (9), pp. 1314-1319. Date of Electronic Publication: 2019 Mar 22. - Publication Year :
- 2019
-
Abstract
- Background: Insulin-like growth factor 1 (IGF-1) and its main binding protein insulin-like growth factor binding protein 3 (IGFBP-3) have been related to several cardiovascular diseases. The relation with atrial fibrillation (AF) is largely unknown.<br />Objective: The objective of this study was to investigate the association of IGF-1 and IGFBP-3 levels with prevalent and incident AF in a large population-based study.<br />Methods: Data from the Study of Health in Pomerania (SHIP) were collected. At presentation, a medical examination, standardized electrocardiographic assessment, and measurements of serum IGF-1 and IGFBP-3 levels were performed. Incident AF was assessed in individuals without AF at baseline (SHIP-1) who developed AF during follow-up (SHIP-2; after a mean of 5.2 years).<br />Results: Of 3160 participants, 66 (2.1%) exhibited AF at baseline. IGF-1 levels and IGF-1/IGFBP-3 ratios were significantly lower in individuals with AF than in those without AF (IGF-1: 104.2 ± 41.6 ng/mL vs 142.9 ± 53.5 ng/mL, P < .001 and IGF-1/IGFBP-3: 0.031 ± (0.009 ng/mL vs 0.036 ± 0.010 ng/mL, P = .006, respectively). Multivariable-adjusted logistic regression models showed that a low IGF-1/IGFBP-3 ratio was associated with prevalent AF (odds ratios 0.67; 95% confidence interval 0.48-0.94; P = .021). Of 1817 individuals without AF at baseline, 27 (1.5%) developed AF during follow-up. In these participants, IGF-1 levels, but not IGF-1/IGFBP-3 ratios, were significantly lower (IGF-1: 113.3 ± 38.6 ng/mL vs 147.2 ± 51.6 ng/mL, P = .013 and IGF-1/IGFBP-3: 0.033 ± 0.008 ng/mL vs 0.036 ± 0.010 ng/mL, P = .176).<br />Conclusion: Low IGF-1/IGFBP-3 ratios are associated with a higher prevalence of AF. There seems to be a similar impact in incident AF.<br /> (Copyright © 2019 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Cohort Studies
Electrocardiography methods
Electrocardiography statistics & numerical data
Female
Germany epidemiology
Humans
Male
Middle Aged
Odds Ratio
Prevalence
Atrial Fibrillation blood
Atrial Fibrillation diagnosis
Atrial Fibrillation epidemiology
Insulin-Like Growth Factor Binding Protein 3 analysis
Insulin-Like Growth Factor I analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1556-3871
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Heart rhythm
- Publication Type :
- Academic Journal
- Accession number :
- 30910708
- Full Text :
- https://doi.org/10.1016/j.hrthm.2019.03.017