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The angiotensin II type 1 receptor blocker azilsartan can overwhelm the sympathetic nerve activation stimulated by coadministration of calcium channel blockers.
- Source :
-
Journal of the renin-angiotensin-aldosterone system : JRAAS [J Renin Angiotensin Aldosterone Syst] 2019 Jan-Mar; Vol. 20 (1), pp. 1470320319839525. - Publication Year :
- 2019
-
Abstract
- Objective:: In our recent study, non-Gaussianity of heart rate variability (λ <subscript>25s</subscript> ), an indicator of sympathetic nerve activity, did not change during two-day treatment with the angiotensin II type 1 receptor blocker (ARB) azilsartan. Coadministration of calcium channel blockers (CCBs) might affect the study results.<br />Methods:: In this subanalysis, 20 patients with chronic kidney disease (14 men; age 61±15 years) were divided into three groups: patients with coadministration of L-type CCB, patients without coadministration of CCB, and patients with coadministration of sympathoinhibitory (L/T- or L/T/N-type) CCB. λ <subscript>25s</subscript> was calculated separately in daytime and nighttime.<br />Results:: Daytime λ <subscript>25s</subscript> at baseline was higher in patients with L-type CCB coadministration (0.62±0.18, n = 5) compared with those without CCB (0.49±0.13, n = 11) and those with sympathoinhibitory CCB (0.46±0.06, n = 4). The relationship between the changes in daytime λ <subscript>25s</subscript> and systolic blood pressure was positive in patients with L-type CCB coadministration, whereas the relationship was inverse in the other two groups. A larger decrease in daytime λ <subscript>25s</subscript> was shown in patients with L-type CCB coadministration compared with those in the other two groups.<br />Conclusions:: CCBs, as well as diuretics, are recommended as second-line antihypertensive agents. Our results suggested that ARBs can overwhelm the activation of sympathetic nerve activity stimulated by coadministration of L-type CCBs.
- Subjects :
- Female
Humans
Male
Middle Aged
Angiotensin II Type 1 Receptor Blockers administration & dosage
Angiotensin II Type 1 Receptor Blockers pharmacology
Benzimidazoles administration & dosage
Benzimidazoles pharmacology
Calcium Channel Blockers administration & dosage
Calcium Channel Blockers pharmacology
Oxadiazoles administration & dosage
Oxadiazoles pharmacology
Sympathetic Nervous System drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1752-8976
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the renin-angiotensin-aldosterone system : JRAAS
- Publication Type :
- Academic Journal
- Accession number :
- 30915878
- Full Text :
- https://doi.org/10.1177/1470320319839525