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Gastrointestinal Hormones Manipulation to Counteract Metabolic Syndrome Using Duodenal Targeted Embolization.
- Source :
-
Surgical innovation [Surg Innov] 2019 Jun; Vol. 26 (3), pp. 280-292. Date of Electronic Publication: 2019 Mar 28. - Publication Year :
- 2019
-
Abstract
- Purpose: Targeted embolization of gastrointestinal (GI) arteries can modify hormonal production. We aimed to evaluate the impact of the embolization of the gastroduodenal artery (GDA) on the activity of foregut mucosa.<br />Methods: The GDA's duodenal branch was embolized in 12 Yucatan pigs using 100-300 µm (group A; n = 4) or 300-500 µm (group B; n = 4) microspheres, followed by coiling of the branch. In 4 animals (sham), only saline was injected. The levels of GI hormones (ghrelin, glucose-dependent insulinotropic peptide [GIP], glucagon-like peptide-1 [GLP-1], insulin, peptide YY [PYY], leptin) and the gene expression of sodium-glucose-linked transporter-1 (SGLT-1) and glucose transporter-2 (GLUT-2) were assessed before (T0), 1 hour (T1), 1 month (T2), 3 months (T3), and 6 months (T4) after embolization.<br />Results: In group A, a segmental duodenal stenosis occurred in all cases, which required balloon dilatation. There was a significant drop in the baseline glycemia in group A at T1 and T4 versus sham. Ghrelin was reduced in group A versus baseline and versus group B at T2 and T3 and versus sham at T1 and T3. Insulin was significantly lower in group A versus B at T1 and at T4 but not versus sham. SGLT-1 expression increased in B and sham at T4, while it remained stable in group A. GLUT-2 expression increased in sham at T4 but not in A or B.<br />Conclusions: GDA embolization induced a decrease in ghrelin production and influenced expression of glucose carriers in the foregut mucosa.
- Subjects :
- Animals
Male
Angiography, Digital Subtraction
Contrast Media administration & dosage
Disease Models, Animal
Intestinal Mucosa metabolism
Swine
Triiodobenzoic Acids administration & dosage
Duodenum blood supply
Duodenum diagnostic imaging
Embolization, Therapeutic methods
Gastrointestinal Hormones metabolism
Metabolic Syndrome metabolism
Metabolic Syndrome prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1553-3514
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Surgical innovation
- Publication Type :
- Academic Journal
- Accession number :
- 30920898
- Full Text :
- https://doi.org/10.1177/1553350619838098