SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism.

Authors :: Benson S
Fernandez A
Barth ND
de Moliner F
Horrocks MH
Herrington CS
Abad JL
Delgado A
Kelly L
Chang Z
Feng Y
Nishiura M
Hori Y
Kikuchi K
Vendrell M
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 May 20; Vol. 58 (21), pp. 6911-6915. Date of Electronic Publication: 2019 Apr 12.
Publication Year :: 2019
Abstract: The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small-sized multi-colored fluorophores for real-time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.<br /> (© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)

Subjects :: A549 Cells
Fluorescent Dyes chemistry
Fluorescent Dyes metabolism
HeLa Cells
Humans
Ionophores
Microscopy, Fluorescence
Neoplasms pathology
Fluorescent Dyes analysis
Green Fluorescent Proteins metabolism
Metabolome
Molecular Imaging methods
Neoplasms metabolism

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