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Mechanisms of Improved Mortality Following Ablation: Does Ablation Restore Beta-Blocker Benefit in Atrial Fibrillation/Heart Failure?
- Source :
-
Cardiology clinics [Cardiol Clin] 2019 May; Vol. 37 (2), pp. 177-183. Date of Electronic Publication: 2019 Feb 27. - Publication Year :
- 2019
-
Abstract
- Observational trials have shown that atrial fibrillation ablation favorably impacts long-term outcomes in systolic heart failure. These outcomes have been confirmed by randomized prospective trials highlighting the favorable impact of ablation on left ventricular function and remodeling, risk of heart failure hospitalization, and mortality. Ablation along with established heart failure medications is new and supported conceptually by the value of restoring sinus rhythm, avoiding long-term antiarrhythmic drugs, and minimizing drug-drug interactions. Observational data suggest a potential long-term benefit of beta-blockers with ablation that becomes augmented as follow-up is extended from 1 to 5 years.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Atrial Fibrillation physiopathology
Atrial Fibrillation surgery
Comorbidity
Global Health
Heart Failure physiopathology
Humans
Postoperative Period
Survival Rate trends
Adrenergic beta-Antagonists therapeutic use
Atrial Fibrillation mortality
Catheter Ablation
Heart Failure mortality
Stroke Volume physiology
Ventricular Function, Left physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1558-2264
- Volume :
- 37
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cardiology clinics
- Publication Type :
- Academic Journal
- Accession number :
- 30926019
- Full Text :
- https://doi.org/10.1016/j.ccl.2019.01.011