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Clinical pharmacokinetics and pharmacodynamics of intravenous alfaxalone in young Thoroughbred horses premedicated with medetomidine and midazolam.
- Source :
-
The Veterinary record [Vet Rec] 2019 Mar 30; Vol. 184 (13), pp. 411. - Publication Year :
- 2019
-
Abstract
- To investigate the clinical pharmacokinetics and pharmacodynamics of intravenous alfaxalone in young Thoroughbred horses, seven Thoroughbred horses were randomly anaesthetised twice with either 1 or 2 mg/kg of intravenous alfaxalone after premedication with medetomidine (6 µg/kg intravenous) and midazolam (20 µg/kg intravenous). Blood samples were collected at predetermined time points up to two hours after administration. Plasma alfaxalone concentrations were quantified by a liquid chromatography tandem-mass spectrometry method and analysed by non-compartmental pharmacokinetic analysis. Induction and recovery qualities were good to excellent for both doses. Recovery time for the 2 mg/kg (median 90 minutes) was significantly longer than that for the 1 mg/kg (median 50 minutes). Respiratory rate for the 2 mg/kg was significantly lower than that for the 1 mg/kg, resulting in hypoxaemia. The median (range) elimination half-life, total clearance and volume of distribution were 58.2 (42.3-70.7) minutes, 11.6 (10.3-14.5) ml/minute/kg and 0.8 (0.7-0.9) l/kg for the 1 mg/kg and 59.8 (47.5-68.0) minutes, 14.7 (12.1-16.0) ml/minute/kg and 0.9 (0.9-1.2) l/kg for the 2 mg/kg, respectively. Alfaxalone is rapidly eliminated from the plasma in young Thoroughbred horses. Respiratory depression should be especially noted when alfaxalone is used in clinical practice.<br />Competing Interests: Competing interests: None declared.<br /> (© British Veterinary Association 2018. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Anesthesia, Intravenous methods
Animals
Cross-Over Studies
Female
Horses
Male
Pregnanediones pharmacokinetics
Pregnanediones pharmacology
Respiratory Rate drug effects
Anesthesia, Intravenous veterinary
Anesthetics, Intravenous pharmacokinetics
Anesthetics, Intravenous pharmacology
Medetomidine therapeutic use
Midazolam therapeutic use
Pregnanediones administration & dosage
Premedication veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 2042-7670
- Volume :
- 184
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- The Veterinary record
- Publication Type :
- Academic Journal
- Accession number :
- 30926700
- Full Text :
- https://doi.org/10.1136/vr.105070