Routine drug resistance testing in proviral HIV-1 DNA: Prevalence of stop codons and hypermutation, and associated factors.

Authors :: Alidjinou EK
Deldalle J
Robineau O
Hallaert C
Meybeck A
Huleux T
Ajana F
Hober D
Bocket L
Source :: Journal of medical virology [J Med Virol] 2019 Sep; Vol. 91 (9), pp. 1684-1687. Date of Electronic Publication: 2019 Apr 13.
Publication Year :: 2019
Abstract: We investigated the presence of stop codons (SC) and/or hypermutation (HM) in HIV-1 DNA sequences generated for routine drug resistance testing in proviral HIV-1 DNA, and sought for associated factors. At least one SC was identified in 6.2% of HIV-1 DNA sequences, among which 54.8% were hypermutated. The defective virus group (SC w/o HM) was similar to the non-SC group regarding the characteristics of HIV-1 infection, and before drug exposure. In addition, the HIV-1 DNA levels were not different between both groups. Sequences with SC/HM displayed a higher proportion of RAMs. The impact of the SC/HM associated RAMs on clinical responses requires further investigation.<br /> (© 2019 Wiley Periodicals, Inc.)

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