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High-density lipoprotein cholesterol for the prediction of mortality in cirrhosis with portal vein thrombosis: a retrospective study.
- Source :
-
Lipids in health and disease [Lipids Health Dis] 2019 Mar 30; Vol. 18 (1), pp. 79. Date of Electronic Publication: 2019 Mar 30. - Publication Year :
- 2019
-
Abstract
- Background: Lipid profiles disorders frequently occur in patients with chronic liver diseases, and the mortality of cirrhosis complicated with portal vein thrombosis (PVT) remains high. Research identifying simple and objective prognosis indicators for cirrhotic PVT has been limited. The aim of the present study was to investigate the association between lipid profiles and liver function, which may help predict the 1-year mortality in non-malignant cirrhosis with PVT.<br />Methods: A retrospective cohort of 117 subjects with non-malignant cirrhotic PVT was conducted. The primary indicators of lipid profiles included triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol. Correlations of lipid profiles with liver function tests, the Child-Turcotte-Pugh (CTP) score and the model for end-stage liver disease (MELD) score were investigated. The relationship between lipid profiles and 1-year mortality was assessed using the area under the receiver operating characteristic curves (AUROC). Logistic regression models were established to confirm the association between HDL-C and mortality.<br />Results: The level of HDL-C was significantly decreased in non-survivors (p < 0.01) and patients with more severe liver damage stages (CTP p < 0.001; MELD p < 0.001). There was no significant difference in the HDL-C level among patients with different severities of PVT (p = 0.498). The level of HDL-C was positively correlated with albumin (p < 0.001, R = 0.438) and platelet (p = 0.022, R = 0.212) levels. The level of HDL-C was negatively correlated with bilirubin (p < 0.001, R = - 0.319), C-reactive protein (p < 0.001, R = - 0.342), the aspartate aminotransferase to alanine aminotransferase ratio (p < 0.0.1, R = - 0.237), the CTP score (p < 0.001, R = - 0.397) and the MELD score (p < 0.001, R = - 0.406). The 1-year mortality rate was 12.8%. The AUROC of HDL-C for the prediction of 1-year mortality in this population was 0.744 (p < 0.01, 95%CI 0.609-0.879). The level of HDL-C was independently associated with mortality by multivariate logistic regression models.<br />Conclusions: The HDL-C level significantly decreases with the deterioration of liver function, which may serve as a potential indicator for the prognosis of non-malignant cirrhotic patients with PVT.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Blood Platelets metabolism
C-Reactive Protein metabolism
Female
Humans
Liver injuries
Liver pathology
Liver Cirrhosis complications
Liver Cirrhosis mortality
Liver Cirrhosis pathology
Male
Middle Aged
Portal Vein pathology
Retrospective Studies
Risk Factors
Severity of Illness Index
Venous Thrombosis complications
Venous Thrombosis mortality
Venous Thrombosis pathology
Cholesterol, HDL blood
Liver Cirrhosis blood
Prognosis
Venous Thrombosis blood
Subjects
Details
- Language :
- English
- ISSN :
- 1476-511X
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Lipids in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 30927926
- Full Text :
- https://doi.org/10.1186/s12944-019-1005-8