Back to Search
Start Over
Rationale and design of the impact of anticoagulation therapy on the Cognitive Decline and Dementia in Patients with Nonvalvular Atrial Fibrillation (CAF) Trial: A Vanguard study.
- Source :
-
Clinical cardiology [Clin Cardiol] 2019 May; Vol. 42 (5), pp. 506-512. Date of Electronic Publication: 2019 Apr 10. - Publication Year :
- 2019
-
Abstract
- Atrial fibrillation (AF) is associated with a risk for cognitive impairment and dementia, which is more pronounced in patients with a history of clinical stroke. Observational trials suggest that the implementation and quality of long-term anticoagulation impact dementia risk. Emerging evidence suggests that direct oral anticoagulants may improve long-term risk of dementia in AF patients. This manuscript describes the rational and trial design of the the Cognitive Decline and Dementia in Atrial Fibrillation Patients (CAF) Trial. CAF investigates if AF patients randomized to dabigatran etexilate will have long-term higher cognition scores and lower rates of dementia compared in the long term to dose-adjusted warfarin (International Normalized Ratio [INR]: 2.0-3.0). As of 27 February 2019, a total of 120 subjects will be enrolled at one investigational site in the United States and will be followed for 2 years after study enrollment. To date, 97 have been enrolled. The average age is 74.2 years, 53% are male, and 9% had a prior stroke. In this Vanguard study, patients will be followed for 2 years after study enrollment. These prospective, randomized data will inform the understanding of two anticoagulants in AF patients as it relates to risk of cognitive decline and dementia. Cranial imaging and biomarkers collected will assist in understanding mechanisms of brain injury.<br /> (© 2019 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.)
- Subjects :
- Aged
Anticoagulants adverse effects
Atrial Fibrillation diagnosis
Atrial Fibrillation epidemiology
Cognitive Dysfunction diagnosis
Cognitive Dysfunction epidemiology
Cognitive Dysfunction psychology
Dabigatran adverse effects
Dementia diagnosis
Dementia epidemiology
Dementia psychology
Female
Humans
Incidence
International Normalized Ratio
Male
Prospective Studies
Randomized Controlled Trials as Topic
Risk Factors
Time Factors
Treatment Outcome
Warfarin adverse effects
Anticoagulants administration & dosage
Atrial Fibrillation drug therapy
Cognition drug effects
Cognitive Dysfunction prevention & control
Dabigatran administration & dosage
Dementia prevention & control
Warfarin administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1932-8737
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 30937935
- Full Text :
- https://doi.org/10.1002/clc.23181