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An In Vitro Study of Aromatic Stacking of Drug Molecules.
- Source :
-
Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2019 Jul; Vol. 30 (7), pp. 1199-1203. Date of Electronic Publication: 2019 Apr 04. - Publication Year :
- 2019
-
Abstract
- In this paper, drug-drug chemical interactions between two different aromatic compounds were studied by mass spectrometry. Specifically, we examined non-covalent complexes (NCX) between paclitaxel, a chemotherapeutic compound, and medications widely used in palliative care for depression, psychosis, and anxiety. It is unknown whether psychotropic medications directly interact with paclitaxel. Here, we use a simple and rapid electrospray ionization mass spectrometry in vitro assay, which has been predictive in the case of neuropeptides, to measure the relative strength of non-covalent interactions. This chemical interaction is most likely due to the overlap of aromatic rings of π-orbitals between paclitaxel and five commonly used medications: diazepam, clonozepam, sertraline, fluoxetine, and haloperidol. Molecular modeling illustrates that differences in the stability of the NCXs are likely due to the distance between the aromatic rings present in both the paclitaxel and antidepressant medications. Graphical Abstract.
- Subjects :
- Anti-Anxiety Agents pharmacology
Antidepressive Agents pharmacology
Antineoplastic Agents, Phytogenic pharmacology
Binding Sites
Diazepam chemistry
Diazepam pharmacology
Drug Interactions
Fluoxetine chemistry
Fluoxetine pharmacology
Haloperidol chemistry
Haloperidol pharmacology
Humans
Models, Molecular
Paclitaxel pharmacology
Sertraline chemistry
Sertraline pharmacology
Spectrometry, Mass, Electrospray Ionization methods
Anti-Anxiety Agents chemistry
Antidepressive Agents chemistry
Antineoplastic Agents, Phytogenic chemistry
Paclitaxel chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1123
- Volume :
- 30
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of the American Society for Mass Spectrometry
- Publication Type :
- Academic Journal
- Accession number :
- 30949967
- Full Text :
- https://doi.org/10.1007/s13361-019-02166-x