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The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery.
- Source :
-
American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2019 Jul; Vol. 74 (1), pp. 36-46. Date of Electronic Publication: 2019 Apr 05. - Publication Year :
- 2019
-
Abstract
- Rationale & Objective: The process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery.<br />Study Design: Prospective cohort.<br />Setting & Participants: 1,444 adults undergoing cardiac surgery in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) cohort.<br />Exposures: Plasma concentrations of 2 proangiogenic markers (vascular endothelial growth factor A [VEGF] and placental growth factor [PGF]) and 1 antiangiogenic marker (soluble VEGF receptor 1 [VEGFR1]), measured pre- and postoperatively within 6 hours after surgery.<br />Outcomes: AKI, long AKI duration (≥7 days), and 1-year all-cause mortality.<br />Analytical Approach: Multivariable logistic regression.<br />Results: Following cardiac surgery, plasma VEGF concentrations decreased 2-fold, and PGF and VEGFR1 concentrations increased 1.5- and 8-fold, respectively. There were no meaningful associations of preoperative concentrations of angiogenic markers with outcomes of AKI and mortality. Higher postoperative VEGF and PGF concentrations were independently associated with lower odds of AKI (adjusted ORs of 0.89 [95% CI, 0.82-0.98] and 0.69 [95% CI, 0.55-0.87], respectively), long AKI duration (0.65 [95% CI, 0.49-0.87] and 0.48 [95% CI, 0.28-0.82], respectively), and mortality (0.74 [95% CI, 0.62-0.89] and 0.46 [95% CI, 0.31-0.68], respectively). In contrast, higher postoperative VEGFR1 concentrations were independently associated with higher odds of AKI (1.56; 95% CI, 1.31-1.87), long AKI duration (1.75; 95% CI, 1.09-2.82), and mortality (2.28; 95% CI, 1.61-3.22).<br />Limitations: Angiogenesis markers were not measured after hospital discharge, so we were unable to determine long-term trajectories of angiogenesis marker levels during recovery and follow-up.<br />Conclusions: Higher levels of postoperative proangiogenic markers, VEGF and PGF, were associated with lower AKI and mortality risk, whereas higher postoperative antiangiogenic VEGFR1 levels were associated with higher risk for AKI and mortality.<br /> (Copyright © 2019 National Kidney Foundation, Inc. All rights reserved.)
- Subjects :
- Aged
Biomarkers blood
Cardiac Surgical Procedures methods
Creatinine blood
Endpoint Determination
Female
Humans
Kidney blood supply
Male
Middle Aged
Neovascularization, Physiologic
Outcome Assessment, Health Care
Prospective Studies
Risk Assessment
United States epidemiology
Acute Kidney Injury blood
Acute Kidney Injury diagnosis
Acute Kidney Injury etiology
Acute Kidney Injury mortality
Cardiac Surgical Procedures adverse effects
Postoperative Complications blood
Postoperative Complications diagnosis
Receptors, Vascular Endothelial Growth Factor blood
Vascular Endothelial Growth Factor A blood
Subjects
Details
- Language :
- English
- ISSN :
- 1523-6838
- Volume :
- 74
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of kidney diseases : the official journal of the National Kidney Foundation
- Publication Type :
- Academic Journal
- Accession number :
- 30955944
- Full Text :
- https://doi.org/10.1053/j.ajkd.2019.01.028