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Aster koraiensis extract lowers postprandial glucose in normoglycemic and high-fat-diet-induced obese mice.
- Source :
-
Food science and biotechnology [Food Sci Biotechnol] 2018 Oct 23; Vol. 28 (2), pp. 563-568. Date of Electronic Publication: 2018 Oct 23 (Print Publication: 2019). - Publication Year :
- 2018
-
Abstract
- The Aster koraiensis extract (ASKO) is a newly developed dietary herbal supplement. In this study, the potent blood glucose-lowering activity of ASKO in vitro and in vivo was investigated. In an in vitro glucose uptake assay, ASKO was found to enhance glucose transport in 3T3-L1 adipocytes. Oral administration of ASKO significantly reduced glucose levels in normoglycemic mice during oral glucose tolerance tests (OGTTs). In a long-term efficacy study, 4 weeks of oral ASKO treatment significantly attenuated blood glucose levels during OGTTs in diet-induced obese (DIO) mice. ASKO also enhanced plasma insulin levels after glucose loading, leading to a reduction in blood glucose levels. In addition, ASKO normalized glucose transporter-4 mRNA expression in the muscles of DIO mice. These results indicate that ASKO has postprandial glucose-lowering effects and could be beneficial in the management of prediabetes or type 2 diabetes mellitus.<br />Competing Interests: Compliance with ethical standardsThe authors declare that they have no conflict of interest.
Details
- Language :
- English
- ISSN :
- 2092-6456
- Volume :
- 28
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Food science and biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 30956869
- Full Text :
- https://doi.org/10.1007/s10068-018-0497-8