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Antiangiogenic Iridoids from Stachys ocymastrum and Premna resinosa.
- Source :
-
Planta medica [Planta Med] 2019 Aug; Vol. 85 (11-12), pp. 1034-1039. Date of Electronic Publication: 2019 Apr 09. - Publication Year :
- 2019
-
Abstract
- In this paper, the isolation of one new iridoid glucoside, 6 β -acetoxyipolamiide (1: ), and thirteen (2: - 14: ) known congeners from two Lamiaceae species, Stachys ocymastrum and Premna resinosa , leaf extracts is reported. The structural determination of the isolated compounds was performed by mono- and bidimensional NMR spectroscopic analysis as well as MS experiments. The isolates were assayed for their antiangiogenic activity by two in vivo models, zebrafish embryos and chick chorioallantoic membrane assays. The compounds with a significant antiangiogenic activity in both assays were β -hydroxyipolamiide (2: ), ipolamiide (3: ), and buddlejoside A <subscript>5</subscript> (8: ). 6- O - α -l-(3″- O-p -Methoxycinnamoyl-4″- O -acetyl)rhamnopyranosyl catalpol (13: ) and 6- O - α -l-(2″- trans -caffeoyl)rhamnopyranosyl catalpol (6: ) showed the best antiangiogenic response on blood vessel growth in zebrafish embryos, whereas saccatoside (10: ) and 6- O - α -l-(2″- O - : p -methoxycinnamoyl-3″- O -acetyl)rhamnopyranosyl catalpol (14: ) resulted in a strong reduction of capillary formation in the chorioallantoic membrane assay.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Animals
Biological Assay
Chick Embryo
Dose-Response Relationship, Drug
Iridoids pharmacology
Magnetic Resonance Spectroscopy
Plant Extracts isolation & purification
Plant Extracts pharmacology
Plant Leaves chemistry
Zebrafish
Angiogenesis Inhibitors pharmacology
Iridoids isolation & purification
Lamiaceae chemistry
Stachys chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0221
- Volume :
- 85
- Issue :
- 11-12
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 30965376
- Full Text :
- https://doi.org/10.1055/a-0889-0412