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A Pediatric Case of Transformed Mycosis Fungoides in a BRCA2 Positive Patient.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2020 Jul; Vol. 42 (5), pp. e361-e364. - Publication Year :
- 2020
-
Abstract
- Cutaneous T-cell lymphomas are very rare in children. Although mycosis fungoides is the most common of these rare cutaneous T-cell lymphomas in children, transformation to an aggressive malignancy remains extremely uncommon, and there are no clear guidelines for clinical management in the pediatric population. In addition, the increased usage of next-generation sequencing for pediatric patients with unusual malignancies may result in the discovery of pathogenic germline mutations, though the association between these mutations and the patient's cancer is not always clear. We present here a unique pediatric case of transformed mycosis fungoides in a patient with BRCA2 mutation.
- Subjects :
- Child, Preschool
Female
Humans
Lymphoma, T-Cell, Cutaneous complications
Lymphoma, T-Cell, Cutaneous genetics
Mycosis Fungoides complications
Mycosis Fungoides genetics
Prognosis
Skin Neoplasms complications
Skin Neoplasms genetics
BRCA2 Protein genetics
Lymphoma, T-Cell, Cutaneous pathology
Mutation
Mycosis Fungoides pathology
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 30969264
- Full Text :
- https://doi.org/10.1097/MPH.0000000000001481