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Association of GSTP1 and ERCC1 polymorphisms with toxicity in locally advanced head and neck cancer platinum-based chemoradiotherapy treatment.
- Source :
-
Head & neck [Head Neck] 2019 Aug; Vol. 41 (8), pp. 2704-2715. Date of Electronic Publication: 2019 Apr 11. - Publication Year :
- 2019
-
Abstract
- Background: Platinum-based chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck squamous-cell carcinomas (HNSCC), and most patients experience serious toxicities. The aim of this study was to investigate the association between candidate genes involved in radiation/platinum pathways and acute toxicity of CRT to determine the predictive value of these polymorphisms for toxicity.<br />Methods: Thirty-six selected single nucleotide polymorphisms (SNPs) in 29 genes were genotyped in 110 patients treated with cisplatin-based CRT. DNA was obtained from blood samples, and SNP analysis was performed using a MassARRAY iPLEX Gold (Sequenom) method.<br />Results: Patients with ERCC1 rs11615-C allele (P = .0066), ERCC1 rs735482-C allele (P = .0204), and ERCC4 rs1799801-C allele (P = .0286) had lower risk of grade 2-3 hematologic toxicity. In addition, the presence of G allele of GSTP1 was associated with a significantly lower risk of severe dysphagia (P = .0004).<br />Conclusion: Polymorphisms in ERCC1 and GSTP1 may act as prognostic factors of acute toxicity during treatment with CRT in HNSCC patients.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Agents therapeutic use
Cisplatin therapeutic use
Female
Genotype
Head and Neck Neoplasms therapy
Humans
Linkage Disequilibrium
Logistic Models
Male
Middle Aged
Neoplasm Staging
Prognosis
Prospective Studies
Risk Factors
Antineoplastic Agents adverse effects
Chemoradiotherapy adverse effects
Cisplatin adverse effects
DNA-Binding Proteins genetics
Endonucleases genetics
Glutathione S-Transferase pi genetics
Head and Neck Neoplasms genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 41
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 30973677
- Full Text :
- https://doi.org/10.1002/hed.25754