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Qualitative dimensions of exertional dyspnea in fibrotic interstitial lung disease.
- Source :
-
Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2019 Aug; Vol. 266, pp. 1-8. Date of Electronic Publication: 2019 Apr 12. - Publication Year :
- 2019
-
Abstract
- Unsatisfied inspiration is commonly reported during exercise by patients with interstitial lung disease (ILD). However, the physiological basis of perceived dyspnea quality in this population has not been evaluated. We examined the relationship between dyspnea quality and indices of ventilatory-mechanical limitations during exercise in patients with fibrotic ILD. Sixteen fibrotic ILD patients (12 male) with a median age of 64 years (range 49-81), FVC 71%-predicted (51-100), and DL <subscript>CO</subscript> 47%-predicted (27-77) performed incremental and constant work-rate cycle exercise tests to exhaustion. Ventilatory responses were recorded at rest, throughout exercise, and at peak exercise. Dyspnea quality was serially assessed using a 4-item list from which participants selected the phrase that best described their breathing compared to rest. Increased work/effort was the dominant descriptor of dyspnea throughout exercise, but with increased selection of unsatisfied inspiration following the inflection point of tidal volume relative to ventilation. Delaying or preventing ILD patients from reaching a critically reduced IRV may have implications for symptom management.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Dyspnea etiology
Female
Humans
Lung Diseases, Interstitial complications
Male
Middle Aged
Pulmonary Fibrosis complications
Dyspnea physiopathology
Exercise physiology
Lung Diseases, Interstitial physiopathology
Physical Exertion physiology
Pulmonary Fibrosis physiopathology
Tidal Volume physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1519
- Volume :
- 266
- Database :
- MEDLINE
- Journal :
- Respiratory physiology & neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 30986534
- Full Text :
- https://doi.org/10.1016/j.resp.2019.04.004