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Qualitative dimensions of exertional dyspnea in fibrotic interstitial lung disease.

Authors :
Schaeffer MR
Guenette JA
Ramsook AH
Molgat-Seon Y
Mitchell RA
Wilkie SS
Dhillon SS
Sheel AW
Ryerson CJ
Source :
Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2019 Aug; Vol. 266, pp. 1-8. Date of Electronic Publication: 2019 Apr 12.
Publication Year :
2019

Abstract

Unsatisfied inspiration is commonly reported during exercise by patients with interstitial lung disease (ILD). However, the physiological basis of perceived dyspnea quality in this population has not been evaluated. We examined the relationship between dyspnea quality and indices of ventilatory-mechanical limitations during exercise in patients with fibrotic ILD. Sixteen fibrotic ILD patients (12 male) with a median age of 64 years (range 49-81), FVC 71%-predicted (51-100), and DL <subscript>CO</subscript> 47%-predicted (27-77) performed incremental and constant work-rate cycle exercise tests to exhaustion. Ventilatory responses were recorded at rest, throughout exercise, and at peak exercise. Dyspnea quality was serially assessed using a 4-item list from which participants selected the phrase that best described their breathing compared to rest. Increased work/effort was the dominant descriptor of dyspnea throughout exercise, but with increased selection of unsatisfied inspiration following the inflection point of tidal volume relative to ventilation. Delaying or preventing ILD patients from reaching a critically reduced IRV may have implications for symptom management.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1878-1519
Volume :
266
Database :
MEDLINE
Journal :
Respiratory physiology & neurobiology
Publication Type :
Academic Journal
Accession number :
30986534
Full Text :
https://doi.org/10.1016/j.resp.2019.04.004