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Serologic Prevalence of Ebola Virus in Equatorial Africa.

Authors :
Steffen I
Lu K
Yamamoto LK
Hoff NA
Mulembakani P
Wemakoy EO
Muyembe-Tamfum JJ
Ndembi N
Brennan CA
Hackett J Jr
Stramer SL
Switzer WM
Saragosti S
Mbensa GO
Laperche S
Rimoin AW
Simmons G
Source :
Emerging infectious diseases [Emerg Infect Dis] 2019 May; Vol. 25 (5), pp. 911-918.
Publication Year :
2019

Abstract

We conducted a serologic survey of 2,430 serum samples collected during 1997-2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization assay and a newly developed luciferase immunoprecipitation system assay. Specimens seroreactive for EBOV were confirmed by using an ELISA. Our results suggest a serologic prevalence of 2%-3.5% in the Republic of the Congo and the Democratic Republic of the Congo, which have reported outbreaks of infection with EBOV. In addition we detected a seroprevalence of 1.3% in southern Cameroon, which indicated a low risk for exposure in this region.

Details

Language :
English
ISSN :
1080-6059
Volume :
25
Issue :
5
Database :
MEDLINE
Journal :
Emerging infectious diseases
Publication Type :
Academic Journal
Accession number :
31002071
Full Text :
https://doi.org/10.3201/eid2505.180115