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CD30L/CD30 protects against psoriasiform skin inflammation by suppressing Th17-related cytokine production by Vγ4 + γδ T cells.
- Source :
-
Journal of autoimmunity [J Autoimmun] 2019 Jul; Vol. 101, pp. 70-85. Date of Electronic Publication: 2019 Apr 18. - Publication Year :
- 2019
-
Abstract
- Psoriasis is a common, autoimmune, chronic inflammatory skin disease. It has been demonstrated that cutaneous T17 cells play an important pro-inflammatory role in the pathogenesis of psoriasis, through the production of various Th17-related cytokines. Our previous studies have demonstrated that CD30L/CD30 signal plays a pivotal role in the differentiation of CD4 <superscript>+</superscript> Th17 cells and Vγ6 <superscript>+</superscript> γδ T17 cells in the gut-associated lymphoid tissues of mouse. However, its effect on the pathogenesis of psoriasis is unknown. Here, we fully prove that CD30L/CD30 signaling plays a novel protective role in the development of psoriasis in mice, through selective inhibition of CCR6 expression and Th17-related cytokine synthesis in the Vγ4 <superscript>+</superscript> γδ T17 cell subset. Meanwhile, treatment with agonistic anti-CD30 mAb had a significant therapeutic effect on our psoriasis mouse model. Therefore, the CD30L/CD30 signaling pathway is an ideal target for antibody therapy, which may become a new approach for the immunobiological treatment of psoriasis.<br /> (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Animals
Biomarkers
Biopsy
CD30 Ligand genetics
Cell Movement genetics
Cell Movement immunology
Disease Susceptibility
Gene Deletion
Gene Expression
Immunophenotyping
Ki-1 Antigen genetics
Male
Mice
Psoriasis pathology
Signal Transduction
CD30 Ligand metabolism
Cytokines biosynthesis
Ki-1 Antigen metabolism
Psoriasis etiology
Psoriasis metabolism
Receptors, Antigen, T-Cell, gamma-delta metabolism
Th17 Cells immunology
Th17 Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9157
- Volume :
- 101
- Database :
- MEDLINE
- Journal :
- Journal of autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 31005389
- Full Text :
- https://doi.org/10.1016/j.jaut.2019.04.009