[Different types of molecular hydrogen donors and their pharmacokinetics in vivo].

Molecular hydrogen (H ₂ ) has been shown to have diverse biomedical effects. As a small molecular gas, hydrogen can be diffused to the target without hindrance. A variety of related hydrogen products used in medical research and public health have been developed. There are various methods of administration of H ₂ , mainly including inhaling hydrogen gas, drinking hydrogen water, injecting hydrogen-saline, orally taking solid-state H ₂ sustained-release agents, and stimulating intestinal microbiomes to produce hydrogen. Pharmacokinetics of H ₂ in vivo vary with methods of administration and thus influence its biomedical effects. This review summarizes the types of H ₂ donors and their pharmacokinetics in vivo.