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Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors.
Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2019 Apr 16; Vol. 24 (8). Date of Electronic Publication: 2019 Apr 16. - Publication Year :
- 2019
-
Abstract
- Bacterial multidrug resistance is becoming a growing problem for public health, due to the development and spreading of bacterial strains resistant to antimicrobials. In this study, the antibacterial and multidrug resistance reversing activity of a series of seleno-carbonyl compounds has been evaluated. The effects of eleven selenocompounds on bacterial growth were evaluated in Staphylococcus aureus , methicillin resistant S. aureus (MRSA), Enterococcus faecalis, Escherichia coli , and Chlamydia trachomatis D. The combination effect of compounds with antibiotics was examined by the minimum inhibitory concentration reduction assay. Their efflux pump (EP) inhibitory properties were assessed using real-time fluorimetry. Relative expressions of EP and quorum-sensing genes were studied by quantitative PCR. Results showed that a methylketone selenoester had remarkable antibacterial activity against Gram-positive bacteria and potentiated the activity of oxacillin in MRSA. Most of the selenocompounds showed significant anti-chlamydial effects. The selenoanhydride and the diselenodiester were active inhibitors of the AcrAB-TolC system. Based on these results it can be concluded that this group of selenocompounds can be attractive potential antibacterials and EP inhibitors. The discovery of new derivatives with a significant antibacterial activity as novel selenocompounds, is of high impact in the fight against resistant pathogens.
- Subjects :
- Chlamydia trachomatis drug effects
Drug Resistance, Multiple, Bacterial drug effects
Enterococcus faecalis drug effects
Escherichia coli drug effects
Methicillin-Resistant Staphylococcus aureus drug effects
Microbial Sensitivity Tests
Staphylococcal Infections drug therapy
Staphylococcal Infections microbiology
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Selenium Compounds chemistry
Selenium Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 24
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 31014009
- Full Text :
- https://doi.org/10.3390/molecules24081487