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Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors.

Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors.

Authors :
Mosolygó T
Kincses A
Csonka A
Tönki ÁS
Witek K
Sanmartín C
Marć MA
Handzlik J
Kieć-Kononowicz K
Domínguez-Álvarez E
Spengler G
Source :
Molecules (Basel, Switzerland) [Molecules] 2019 Apr 16; Vol. 24 (8). Date of Electronic Publication: 2019 Apr 16.
Publication Year :
2019

Abstract

Bacterial multidrug resistance is becoming a growing problem for public health, due to the development and spreading of bacterial strains resistant to antimicrobials. In this study, the antibacterial and multidrug resistance reversing activity of a series of seleno-carbonyl compounds has been evaluated. The effects of eleven selenocompounds on bacterial growth were evaluated in Staphylococcus aureus , methicillin resistant S. aureus (MRSA), Enterococcus faecalis, Escherichia coli , and Chlamydia trachomatis D. The combination effect of compounds with antibiotics was examined by the minimum inhibitory concentration reduction assay. Their efflux pump (EP) inhibitory properties were assessed using real-time fluorimetry. Relative expressions of EP and quorum-sensing genes were studied by quantitative PCR. Results showed that a methylketone selenoester had remarkable antibacterial activity against Gram-positive bacteria and potentiated the activity of oxacillin in MRSA. Most of the selenocompounds showed significant anti-chlamydial effects. The selenoanhydride and the diselenodiester were active inhibitors of the AcrAB-TolC system. Based on these results it can be concluded that this group of selenocompounds can be attractive potential antibacterials and EP inhibitors. The discovery of new derivatives with a significant antibacterial activity as novel selenocompounds, is of high impact in the fight against resistant pathogens.

Details

Language :
English
ISSN :
1420-3049
Volume :
24
Issue :
8
Database :
MEDLINE
Journal :
Molecules (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
31014009
Full Text :
https://doi.org/10.3390/molecules24081487