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Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction.

Authors :
Hruby VJ
Source :
Peptides [Peptides] 2019 Jun; Vol. 116, pp. 63-67. Date of Electronic Publication: 2019 Apr 20.
Publication Year :
2019

Abstract

The current opioid crisis has created a tragic problem in medicine and society. Pain is the most ubiquitous and costly disease in society and yet all of our "treatments" have toxicities, especially for prolonged use. However, there are several alternatives that have been discovered in the past fifteen years that have been demonstrated in animals to have none of the toxicities of current drugs. Many of the compounds are multivalent and have novel biological activity profiles. Unfortunately, none of these have been in clinical trials in humans, perhaps because they were discovered in academic laboratories. A review of these novel chemicals are given in this paper.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1873-5169
Volume :
116
Database :
MEDLINE
Journal :
Peptides
Publication Type :
Academic Journal
Accession number :
31014958
Full Text :
https://doi.org/10.1016/j.peptides.2019.02.004