Back to Search
Start Over
Is lipid goal one-size-fits-all: A review of evidence for recommended low-density lipoprotein treatment targets in Asian patients.
- Source :
-
European journal of preventive cardiology [Eur J Prev Cardiol] 2019 Sep; Vol. 26 (14), pp. 1496-1506. Date of Electronic Publication: 2019 Apr 25. - Publication Year :
- 2019
-
Abstract
- The international guideline recommendations for low-density lipoprotein cholesterol (LDL-C) lowering were made based on the results of randomized controlled trials (RCTs), meta-analyses, and observational studies mostly in the White population. It was not clear whether these LDL-C targets could be applicable to other ethnic groups, for example, Asian patients. This review aimed to address major aspects related to the lipid goal and statin therapy in Asia, including the epidemiology of cardiovascular disease, the LDL-C profiles, the lipid goals from localized guidelines, genetics and lifestyles, and the efficacy and safety of statins. Owing to the geographic, ethnic, genetic, and cultural diversity in this region, we observed a geographic pattern of diversity in cardiovascular epidemiology and statin response in Central Asia, East Asia (particularly for Asia-Pacific region), and South Asia. The rapidly growing literature from Asian countries questioning "lower is better" hypothesis was noticed. However, owing to the nature of these dominantly observational data, the conclusion was hardly confirmative. Despite the rapid expansion of the current literature in this region, efforts should be made to ensure an adequate sample size to assess the significance of a given lipid parameter on overall cardiovascular outcomes in this Asian population.
- Subjects :
- Asia epidemiology
Asian People
Biomarkers blood
Cardiovascular Diseases diagnosis
Cardiovascular Diseases ethnology
Down-Regulation
Dyslipidemias blood
Dyslipidemias diagnosis
Dyslipidemias ethnology
Genetic Predisposition to Disease
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects
Life Style ethnology
Risk Assessment
Risk Factors
Treatment Outcome
Cardiovascular Diseases prevention & control
Cholesterol, LDL blood
Dyslipidemias drug therapy
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2047-4881
- Volume :
- 26
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- European journal of preventive cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 31023098
- Full Text :
- https://doi.org/10.1177/2047487319843077