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Thyroid-Like Follicular Carcinoma of the Kidney With Extensive Sarcomatoid Differentiation: A Case Report and Review of the Literature.
- Source :
-
International journal of surgical pathology [Int J Surg Pathol] 2019 Sep; Vol. 27 (6), pp. 678-683. Date of Electronic Publication: 2019 Apr 28. - Publication Year :
- 2019
-
Abstract
- Thyroid-like follicular carcinoma of the kidney (TLFCK) is an extremely rare primary renal malignancy that typically has an indolent course and good prognosis. Histologically, this tumor mimics follicular carcinoma of the thyroid; however, typical thyroid markers are negative. There are fewer than 40 cases reported in the literature, and thus, the prognosis and course of disease is not well understood. Sarcomatoid differentiation has never been reported in a case of TLFCK. We present a case of a 48-year-old woman with an aggressive TLFCK with extensive sarcomatoid differentiation and metastatic disease at presentation. We performed targeted next-generation sequencing of both the thyroid-like component and the poorly differentiated sarcomatoid component using our solid tumor panel to evaluate for any disease-associated mutations and to better understand the molecular profile of these tumors.
- Subjects :
- Adenocarcinoma, Follicular pathology
Adenocarcinoma, Follicular secondary
Biomarkers, Tumor analysis
Biomarkers, Tumor genetics
Carcinoma, Renal Cell pathology
Carcinoma, Renal Cell secondary
Diagnosis, Differential
Fatal Outcome
Female
Humans
Kidney pathology
Kidney surgery
Kidney Neoplasms pathology
Kidney Neoplasms secondary
Middle Aged
Neoplasms, Complex and Mixed pathology
Nephrectomy
Sarcoma pathology
Thyroid Neoplasms diagnosis
Thyroid Neoplasms pathology
Adenocarcinoma, Follicular diagnosis
Carcinoma, Renal Cell diagnosis
Kidney Neoplasms diagnosis
Neoplasms, Complex and Mixed diagnosis
Sarcoma diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1940-2465
- Volume :
- 27
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of surgical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 31032708
- Full Text :
- https://doi.org/10.1177/1066896919845490