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N-Glycosylation in progression of skin cancer.
- Source :
-
Medical oncology (Northwood, London, England) [Med Oncol] 2019 Apr 29; Vol. 36 (6), pp. 50. Date of Electronic Publication: 2019 Apr 29. - Publication Year :
- 2019
-
Abstract
- Skin cancer can be classified as cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Due to the high level of morbidity and mortality, skin cancer has become a global public health issue worldwide while the pathogenesis of skin cancer is still unclear. It is necessary to further identify the pathogenesis of skin cancer and find candidate targets to diagnose and treat skin cancer. A variety of factors are known to be associated with skin cancer including N-glycosylation, which partly explained the malignant behaviors of skin cancer. In this review, we retrieved databases such as PubMed and Web of Science to elucidate its relationship between glycosylation and skin cancer. We summarized some key glycosyltransferases and proteins during the process of N-glycosylation related to skin cancer, which was helpful to unmask the additional mechanism of skin cancer and find some novel targets of skin cancer.
- Subjects :
- Carcinoma, Basal Cell enzymology
Carcinoma, Basal Cell metabolism
Carcinoma, Basal Cell pathology
Carcinoma, Squamous Cell enzymology
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell pathology
Glycosylation
Glycosyltransferases genetics
Glycosyltransferases metabolism
Humans
Melanoma enzymology
Melanoma metabolism
Melanoma pathology
Signal Transduction
Skin Neoplasms enzymology
Skin Neoplasms pathology
Melanoma, Cutaneous Malignant
Biomarkers, Tumor metabolism
Glycoproteins metabolism
Skin Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1559-131X
- Volume :
- 36
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Medical oncology (Northwood, London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 31037368
- Full Text :
- https://doi.org/10.1007/s12032-019-1270-4