WASF3 expression correlates with poor prognosis in gastric cancer patients.

Authors :: Nie Y
Hu S
Liu S
Fang N
Guo F
Yang L
Liang X
Source :: Future oncology (London, England) [Future Oncol] 2019 May; Vol. 15 (14), pp. 1605-1615. Date of Electronic Publication: 2019 Apr 30.
Publication Year :: 2019
Abstract: Aim: WASF3 has been shown to be required for invasion and metastasis in different cancers, this study is to explore the prognostic value of WASF3 in gastric cancer.  Materials & methods: The coexpression of WASF3 and E-cadherin in gastric cancer patients and cells were evaluated. Results: WASF3 was overexpressed and the expression of E-cadherin was decreased in gastric cancer tissues compared with normal tissues (p < 0.001). WASF3 expression is associated with decreased expression of E-cadherin (p = 0.002). Patients with WASF3-positive expression had a poorer prognosis. The multivariate analysis showed that WASF3 expression is an independent prognostic factor related to overall survival (p = 0.027). Conclusion:  Our analysis demonstrates that WASF3 expression correlates with poor outcomes and is a potential prognostic factor in gastric cancer patients.