A Novel Double Core-Shell Bionanoparticle Formed by Ferritin and Baculoviral Polyhedrin.

In this study, we got a step forward of the baculoviral polyhedrin (Polh) exploitation as a new nanobiomaterial. We recruited human H-chain ferritin (FTH) as scaffold and Gaussia luciferase (hGluc) as luminescent signal molecule, preparation, characterization and luminescent analysis of the bionanoparticles formed by the fusion proteins of them mentioned above inspire us to present a view that baculoviral polyhedrin is a nanobrick to be a new nanobiomaterial. The bionanoparticle that formed by FTH and Polh fusion protein is a novel double core-shell structure. The properties of baculoviral polyhedrin make itself a promising new nanobiomaterial for application in bionanotechnology.