Back to Search
Start Over
Incidence and Clinical Impact of Recurrent Takotsubo Syndrome: Results From the GEIST Registry.
- Source :
-
Journal of the American Heart Association [J Am Heart Assoc] 2019 May 07; Vol. 8 (9), pp. e010753. - Publication Year :
- 2019
-
Abstract
- Background Current literature only reports variable information from single-center studies on the recurrence rate, the complications, and the outcome of patients with Takotsubo syndrome ( TTS) experiencing recurrent TTS . Therefore, a detailed description of clinical characteristics, predictors, and the prognostic impact of patients with TTS and recurrences in a multicenter registry is needed. Methods and Results We analyzed 749 patients with TTS from 9 European centers being part of the international, multicenter GEIST (German Italian Stress Cardiomyopathy) Registry. Patients were divided into the recurrence group and the nonrecurrence group. The recurrence rate at a median follow-up of 830 days (interquartile range, 118-1701 days) was 4%. Most recurrences were documented in the first 5 years after the index TTS episode. Up to 2 TTS recurrences were documented in 2 of 30 patients (6%). A variable ballooning pattern (n=6, 0.8%) with, in particular, involvement of the right ventricular occurred in 3 cases (0.4%) at the recurrence event. Except for the higher presence of arterial hypertension (86.7% versus 68.3%; P=0.03) in the recurrence group, no other baseline characteristics were different between groups. Observation of TTS complications during follow-up, including stroke, thromboembolic events, in-hospital death, and cardiogenic shock, revealed no significant differences between groups ( P>0.05), except the higher presence of pulmonary edema in the recurrence group versus the nonrecurrence group (13.3% versus 4.9%; P=0.04). Conclusions The incidence of TTS recurrence is estimated to be 4% in this multicenter TTS registry. A variable TTS pattern at recurrence is common in up to 20% of recurrence cases.
- Subjects :
- Aged
Aged, 80 and over
Female
Germany epidemiology
Hospital Mortality
Humans
Incidence
Italy epidemiology
Male
Middle Aged
Proportional Hazards Models
Recurrence
Registries
Shock, Cardiogenic epidemiology
Stroke epidemiology
Stroke Volume
Takotsubo Cardiomyopathy complications
Takotsubo Cardiomyopathy physiopathology
Thromboembolism epidemiology
Ventricular Dysfunction, Left etiology
Ventricular Dysfunction, Left physiopathology
Ventricular Dysfunction, Right etiology
Ventricular Dysfunction, Right physiopathology
Hypertension epidemiology
Takotsubo Cardiomyopathy epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2047-9980
- Volume :
- 8
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of the American Heart Association
- Publication Type :
- Academic Journal
- Accession number :
- 31046506
- Full Text :
- https://doi.org/10.1161/JAHA.118.010753