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Mesenchymal stem cells-curcumin loaded chitosan nanoparticles hybrid vectors for tumor-tropic therapy.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2019 Aug 01; Vol. 134, pp. 1002-1012. Date of Electronic Publication: 2019 May 04. - Publication Year :
- 2019
-
Abstract
- The combination of controlled release technology and targeted drug delivery has become a promising strategy for cancer therapy. In this study, cell-nanoparticle hybrid vector was constructed using mesenchymal stem cells as the targeting cellular carrier and biotinylated chitosan polymer nanoparticles as the drug depot. Drug-loaded nanoparticles (hydrodynamic size =377.0 ± 14.6 nm and zeta potential = 9.6 ± 1.9 mV) were prepared by encapsulating hydrophobic model drug curcumin into biotinylated chitosan polymer. The biotin-modified nanoparticles were anchored on biotinylated mesenchymal stem cells surface by biotin-avidin binding, achieving an upload of 54.73 ± 3.95 pg/cell. The anchorage of nanoparticles on mesenchymal stem cells had no effect on their viability and homing property. Biotin-avidin binding lasted over 48 h, which could be sufficient for cell-directed tumor-tropic delivery. The in vitro and in vivo anti-tumor results advocate that cell-nanoparticle hybrid vector could prove beneficial in pulmonary melanoma metastasis therapy.<br /> (Copyright © 2019. Published by Elsevier B.V.)
- Subjects :
- Animals
Biotin
Cell Movement drug effects
Cell Survival drug effects
Curcumin chemistry
Disease Models, Animal
Drug Delivery Systems
Drug Liberation
Fluorescent Antibody Technique
Male
Mesenchymal Stem Cells drug effects
Mice
Neoplasms therapy
Polymers
Tumor Burden drug effects
Xenograft Model Antitumor Assays
Chitosan chemistry
Curcumin administration & dosage
Drug Carriers chemistry
Mesenchymal Stem Cell Transplantation methods
Mesenchymal Stem Cells metabolism
Nanoparticles chemistry
Nanoparticles ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 134
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 31063785
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2019.04.201