Back to Search Start Over

Mesenchymal stem cells-curcumin loaded chitosan nanoparticles hybrid vectors for tumor-tropic therapy.

Authors :
Xu M
Asghar S
Dai S
Wang Y
Feng S
Jin L
Shao F
Xiao Y
Source :
International journal of biological macromolecules [Int J Biol Macromol] 2019 Aug 01; Vol. 134, pp. 1002-1012. Date of Electronic Publication: 2019 May 04.
Publication Year :
2019

Abstract

The combination of controlled release technology and targeted drug delivery has become a promising strategy for cancer therapy. In this study, cell-nanoparticle hybrid vector was constructed using mesenchymal stem cells as the targeting cellular carrier and biotinylated chitosan polymer nanoparticles as the drug depot. Drug-loaded nanoparticles (hydrodynamic size =377.0 ± 14.6 nm and zeta potential = 9.6 ± 1.9 mV) were prepared by encapsulating hydrophobic model drug curcumin into biotinylated chitosan polymer. The biotin-modified nanoparticles were anchored on biotinylated mesenchymal stem cells surface by biotin-avidin binding, achieving an upload of 54.73 ± 3.95 pg/cell. The anchorage of nanoparticles on mesenchymal stem cells had no effect on their viability and homing property. Biotin-avidin binding lasted over 48 h, which could be sufficient for cell-directed tumor-tropic delivery. The in vitro and in vivo anti-tumor results advocate that cell-nanoparticle hybrid vector could prove beneficial in pulmonary melanoma metastasis therapy.<br /> (Copyright © 2019. Published by Elsevier B.V.)

Details

Language :
English
ISSN :
1879-0003
Volume :
134
Database :
MEDLINE
Journal :
International journal of biological macromolecules
Publication Type :
Academic Journal
Accession number :
31063785
Full Text :
https://doi.org/10.1016/j.ijbiomac.2019.04.201