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Macrophage markers soluble CD163 and soluble mannose receptor are associated with liver injury in patients with paracetamol overdose.
- Source :
-
Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2019 May; Vol. 54 (5), pp. 623-632. Date of Electronic Publication: 2019 May 08. - Publication Year :
- 2019
-
Abstract
- The macrophage activation markers, soluble CD163 (sCD163) and soluble mannose receptor (sMR), are associated with liver disease severity and prognosis. We aimed to investigate macrophage activation reflected by sMR and sCD163 in patients with mild and severe paracetamol (PCM) intoxication and effects of antidote treatment in patients and healthy controls. We measured sMR and sCD163 levels by in-house enzyme-linked immunosorbent assays in two independent prospective cohorts of PCM overdosed patients: 49 patients with early mild PCM overdose from Aarhus University Hospital and 30 patients with severe acute liver injury included at the Royal Infirmary of Edinburgh. Furthermore, we investigated sMR and sCD163 in 14 healthy controls during N -acetylcysteine treatment. Within the mild PCM cohort, patients with elevated alanine transaminase on admission had significantly higher levels of sCD163 compared with patients with normal alanine transaminase (2.92[2.00-5.75] versus 1.29[1.02-1.69] mg/L, p = .009), whereas sMR showed no significant difference. In patients with acute liver injury, both markers were markedly higher compared to the mild PCM cohort (sCD163: 10.73[5.79-14.62] versus 1.34[1.06-1.96], p < .001; sMR: 0.80[0.63-1.14] versus 0.18[0.14-0.25], p < .001). Antidote treatment significantly reduced sCD163 levels in both PCM overdosed patients and healthy controls. In conclusion, macrophage activation assessed by the levels of sMR and sCD163 is associated with the degree of liver injury in patients with PCM intoxication and is ameliorated by antidote treatment, suggesting macrophage involvement in PCM-induced liver injury.
- Subjects :
- Adult
Antidotes therapeutic use
Antigens, CD drug effects
Antigens, Differentiation, Myelomonocytic drug effects
Biomarkers blood
Case-Control Studies
Chemical and Drug Induced Liver Injury drug therapy
Chemical and Drug Induced Liver Injury etiology
Drug Overdose therapy
Female
Humans
Lectins, C-Type drug effects
Linear Models
Male
Mannose Receptor
Mannose-Binding Lectins drug effects
Middle Aged
Prognosis
Prospective Studies
Receptors, Cell Surface drug effects
Young Adult
Acetaminophen poisoning
Analgesics, Non-Narcotic poisoning
Antigens, CD blood
Antigens, Differentiation, Myelomonocytic blood
Chemical and Drug Induced Liver Injury blood
Lectins, C-Type blood
Macrophage Activation
Mannose-Binding Lectins blood
Receptors, Cell Surface blood
Subjects
Details
- Language :
- English
- ISSN :
- 1502-7708
- Volume :
- 54
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 31067143
- Full Text :
- https://doi.org/10.1080/00365521.2019.1608292