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Euphorkanlide A, a Highly Modified Ingenane Diterpenoid with a C 24 Appendage from Euphorbia kansuensis.
- Source :
-
Organic letters [Org Lett] 2019 Jun 07; Vol. 21 (11), pp. 4128-4131. Date of Electronic Publication: 2019 May 14. - Publication Year :
- 2019
-
Abstract
- Euphorkanlide A (1), a highly modified ingenane diterpenoid with a C <subscript>24</subscript> appendage forming an additional hexahydroisobenzofuran-fused 19-membered macrocyclic bis-lactone ring system was isolated from the roots of Euphorbia kansuensis. Its structure was determined by extensive spectroscopic analysis and quantum-chemical calculations. Compound 1 showed significant cytotoxicities against a panel of cancer cell lines (IC <subscript>50s</subscript> < 5 μM). Mechanistic study revealed that 1 could induce the generation of ROS, leading to cell cycle arrest and cell apoptosis in drug-resistant cancer cell line HCT-15/5-FU.
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Apoptosis drug effects
Cell Cycle Checkpoints drug effects
Cell Line, Tumor
Cell Proliferation drug effects
Diterpenes chemistry
Diterpenes isolation & purification
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm drug effects
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Structure-Activity Relationship
Antineoplastic Agents, Phytogenic pharmacology
Diterpenes pharmacology
Euphorbia chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 21
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 31083958
- Full Text :
- https://doi.org/10.1021/acs.orglett.9b01315