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Salmonella enterica Serovar Typhimurium Interacts with CD209 Receptors To Promote Host Dissemination and Infection.
- Source :
-
Infection and immunity [Infect Immun] 2019 Jul 23; Vol. 87 (8). Date of Electronic Publication: 2019 Jul 23 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.<br /> (Copyright © 2019 American Society for Microbiology.)
- Subjects :
- Animals
Antigen-Presenting Cells microbiology
Female
Host-Pathogen Interactions
Humans
Lipopolysaccharides physiology
Mannans pharmacology
Mice
Mice, Inbred C57BL
O Antigens physiology
Peyer's Patches physiology
Phagocytosis
RAW 264.7 Cells
Cell Adhesion Molecules physiology
Lectins, C-Type physiology
Receptors, Cell Surface physiology
Salmonella typhimurium pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5522
- Volume :
- 87
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 31085704
- Full Text :
- https://doi.org/10.1128/IAI.00100-19