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Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
- Source :
-
Nature communications [Nat Commun] 2019 May 14; Vol. 10 (1), pp. 2154. Date of Electronic Publication: 2019 May 14. - Publication Year :
- 2019
-
Abstract
- Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.
- Subjects :
- Asian People genetics
Case-Control Studies
Colorectal Neoplasms pathology
Datasets as Topic
Female
Genome-Wide Association Study
Humans
Inheritance Patterns
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
White People genetics
Colorectal Neoplasms genetics
Genetic Loci
Genetic Predisposition to Disease
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 31089142
- Full Text :
- https://doi.org/10.1038/s41467-019-09775-w