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Role of extracellular vesicles in stem cell biology.
- Source :
-
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2019 Aug 01; Vol. 317 (2), pp. C303-C313. Date of Electronic Publication: 2019 May 15. - Publication Year :
- 2019
-
Abstract
- The extracellular vesicles (EVs) are membrane vesicles carrying proteins, nucleic acids, and bioactive lipids of the cell of origin. These vesicles released within the extracellular space and entering into the circulation may transfer their cargo to neighboring or distant cells and induce phenotypical and functional changes that may be relevant in several physiopathological conditions. In an attempt to define the biological properties of EVs, several investigations have focused on their cargo and on the effects elicited in recipient cells. EVs have been involved in modulation of tumor microenvironment and behavior, as well as in the immune and inflammatory response. In the present review, we address the paracrine action of EVs released by stem cells and their potential involvement in the activation of regenerative programs in injured cells.
- Subjects :
- Animals
Exosomes genetics
Exosomes immunology
Exosomes pathology
Humans
Inflammation immunology
Inflammation metabolism
Inflammation pathology
Neoplasms immunology
Neoplasms metabolism
Neoplasms pathology
Neoplastic Stem Cells immunology
Neoplastic Stem Cells metabolism
Neoplastic Stem Cells pathology
Paracrine Communication
Signal Transduction
Stem Cells immunology
Stem Cells pathology
Tumor Microenvironment
Exosomes metabolism
Stem Cell Niche
Stem Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1563
- Volume :
- 317
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Cell physiology
- Publication Type :
- Academic Journal
- Accession number :
- 31091143
- Full Text :
- https://doi.org/10.1152/ajpcell.00129.2019